Choroidal melanoma metastasizing to maxillofacial bones

Fulminant hepatic failure due to metastatic choroidal melanoma

Monosomy 3 predicts death but not time until death in choroidal melanoma.

PURPOSE To study whether monosomy 3 can predict time until death caused by metastatic melanoma, whether life expectancy can be predicted in patients after surgical excision of a melanoma displaying monosomy 3, and to confirm the prognostic value of monosomy 3 and its correlation with tumor histology. METHODS Archival specimens from 71 patients who died of metastatic melanoma and 40 patients w...

Microcirculation and tumor-infiltrating macrophages in choroidal and ciliary body melanoma and corresponding metastases.

PURPOSE To investigate the relationship between progression to hepatic metastasis and tumor-infiltrating macrophages and microcirculation attributes in uveal melanoma, a cancer that almost invariably disseminates hematogenously to the liver. METHODS A cross-sectional histopathologic analysis of 48 hepatic metastases and corresponding primary choroidal and ciliary body melanomas was conducted,...

Analysis of chromosomal aberration (1, 3, and 8) and association of microRNAs in uveal melanoma

PURPOSE Uveal melanoma is the most common intraocular primary tumor, involving iris, ciliary body and choroid. More than 90% of the patients develop hepatic metastasis with an average survival time of 7 months. We have used formalin fixed paraffin embedded sections to validate the presence of monosomy 3, an accurate predictor of metastasis, chromosome 8 isochromosome (8q22), and 1p36 deletion. ...

De novo Evolution of a Small Choroidal Melanoma.

AIM To report the evolution of a de novo choroidal melanoma. METHOD This is a case report of a 22-year-old white male patient who has been undergoing periodic examination for a choroidal 'freckle' since 10 years of age. RESULTS In 2007, a fundus photograph of the left eye showed a nondescript area of choroidal hyperpigmentation temporal to the fovea. Progressive growth was observed and, by ...